Re: Time to event variable

From: Matthew Riggs riggsmm@yahoo.com Subject: Re: [NMusers] Time to event variable Date: Fri, 25 Aug 2006 05:55:28 -0700 (PDT) Hi Wenhui, There's an example that may help you by Cox and Sheiner (Repeated measures time to event with time-varying concentration and hazard) - implementation information is available at: ftp://ftp.globomaxnm.com/Public/nonmem/non_continuous/ Start with the 'readme' file and then the data formatting & NONMEM control file examples are in the "general_hazard" folder. The literature reference is: Cox et al. A population pharmacokinetic-pharmacodynamic analysis of repeated measures time-to-event pharmacodynamic responses: the antiemetic effect of ondansetron. J Pharmacokinet Biopharm 1999; 27(6):625-44. Hope this helps. Regards, Matt =-=-=-=-=-=-=-=-=-=-=-=-=-= Matthew M. Riggs, Ph.D Principal Scientist Metrum Research Group LLC 2 Tunxis Road, Suite 112 Tariffville, CT 06081 email: mattr@metrumrg.com www.metrumrg.com _______________________________________________________