How to determine the initial estimates?Thanks

From: "jiang zhigang" jiangzhigangchn@hotmail.com Subject: [NMusers] How to determine the initial estimates?Thanks Date: Fri, 18 Aug 2006 17:29:40 +0800 Dear all, The most puzzle to me when I read the NONMEM User Guide is the "initial estimates"! I don't know why the author knew the initial estimates of THETA,ETA,OMIGA,etc.How does he do? What about the LOWER BOUND and UPPER BOUND? These parameters are exactly what we want NONMEM to work out for us!So,why I know their initial estimates before I figure them out? If I know them before NONMEM's computation ,Why I need NONMEM work for me? Thanks a lot! Jiang _______________________________________________________