How can I determine cl=theta1 or v=theta1?
From: "jiang zhigang" jiangzhigangchn@hotmail.com
Subject: [NMusers] How can I determine cl=theta1 or v=theta1?
Date: Tue, 08 Aug 2006 22:18:24 +0800
Dear,all,
The nonmem guide said,for ADVAN1 TRANS2, NONMEM requires code for CL and V.
then,
How can I determine cl=theta1 or v=theta1?
If I choose cl=theta1 and v=theta2,k =cl/v=theta1/theta2;
but , if I choose v=theta1 and cl = theta2,then k=cl/v= theta2/theta1,
So the value of k will be entirely different at last!
e.g. ,let theta1=4 theta2=2,I'll get 2 different results respectively!
cl=theta1=4 v=theta2=2, k =cl/v=theta1/theta2=4/2=2
another,
v=theta1=4 cl=theta2=2,then k=cl/v= theta2/theta1=2/4=0.5
Look,This is my puzzle!
Can you give me some directions?
Thank you very much!