RE: Reporting of interim models in Pop PK Reports

From: "Diane R Mould" drmould@attglobal.net Subject: RE: [NMusers] Reporting of interim models in Pop PK Reports Date: Tue, 18 Jul 2006 10:54:50 -0400 Hi All I tend to do the same thing that Bill does I include a model table (actually there are usually several tables for different stages of model development) with as much information as possible in the tables, then control stream and output listing for key runs which usually are base, full and final models. "Lack of effect" is to me a difficult question to address using Nonmem, and therefore if the purpose of the evaluation was to show a lack of effect there would be considerable supportive evaluations to answer that question. If I were only looking at covariates and trying to show that there was no apparent impact of a covariate on the PK, eta plots would be as or more useful than a Nonmem run that shows no improvement in stated criteria Diane