Installation of NONMEM using NMQual.

From: "Ramajogi" ramajogi@clinapps.com Subject: [NMusers] Installation of NONMEM using NMQual. Date: Mon, 24 Apr 2006 14:00:18 -0700 Hi All, As of now we are installing NONMEM manually in the following way on Linux (1.1 Red Hat Linux ES V3.0) 1. Log in as root and open a terminal emulation window. 2. Type "csh" in terminal and press Enter. Create the NONMEM installation directory, "mkdir /opt/nmv". 3. Change to the NONMEM installation directory, "cd /opt/nmv". 4. Copy the tar files for NONMEM to /opt/nmv. Note:-Unzip REDHAT\NONMEM.zip folder in FTP server. Copy tar files from NONMem\Nonmem_V.1.1\UNIX folder. 5. Type following command to untar disk1 file."tar xvf disk1.tar". 6. Type following command to untar disk3 file. "tar xvf disk3.tar". 7. Make a NONMEM help directory, "mkdir /opt/nmv/help". 8. Move the help tar file to the help, "mv help.tar help/help.tar". 9. Change to the help directory, "cd help". Untar the help, "tar xvf help.tar". 10. Change back to the NonMem install directory, "cd ..". 11. Run SETUP with the appropriate command line arguments, "./SETUP /opt/nmv g77 -O3 /usr/bin/ar Intel". 12. At Step 6. of SETUP (compiling the source files), Find /opt/nmv/nm folder and check file BEGIN.f. and open this file in Text editor. Un-comment lines 13 and 14 ("OPEN (6, "OUTPUT)" and "REWIND 6"). 13. Check file BLKDAT.f. in /opt/nmv/nm folder. And open this file in Text editor. Change the second instance of "/dev/null" (the value for FNINT) to '/dev/stdout'. 14. Open CFILES.f from /opt/nmv/nm in a text editor and check that at line 46 code is written like "CLOSE(UN(28))". If not and is written like "CLOSE(UN(28),STATUS=DELETED)" , then change code at line as "CLOSE (UN(28))" 15. Allow SETUP to proceed to a successful termination by typing "Y" at step 6. 16. Change to the run directory, "cd run". 17. Test the installation with the nmfe5 C-shell script "./nmfe5 CONTROL5 report5.txt". If successful and you set up NONMEM for PDx-Pop, the file "OUTPUT" will contain the results of the run. If successful and you set up NONMEM for running with nmfe5, the file "report5.txt" will contain the results of the run. But now, one of our clients wants to install NONMEM using NMQual. In that case, the changes in step 12 above is done by NMQual. But the other changes in steps 13 and 14 are not done. Now the Question is what is the need of installing NONMEM with NMQual? If the changes mentioned in step 13 and 14 are not done, how it will effect the NONMEM execution. Thanks in advance Ramajogi ramajogi@clinapps.com www.clinapps.com