Sequential PK/PD approach Query
From: David pkpd500@yahoo.com
Subject: [NMusers] Sequential PK/PD approach Query
Date: Mon, 20 Feb 2006 18:44:51 -0800 (PST)
Dear Users,
I had question regarding "sequential PkPD approach". Lets say we have Pk info from
one group and another gives PD with different pk & pd sampling schemes.
for simplicity sake both the groups considered similar.
1. Since the PD group is different what kind of PK predictions does NONMEM use
to estimate PD ??
2. Is there a way to know them ??
3. suggestions on setting up of Data file since we have 2 different groups of
population with different sampling times.
Thanks !!
David