RE: PD modeling of dataset with opposite values in the measurement effect

From: Paul Hutson prhutson@pharmacy.wisc.edu Subject: RE: [NMusers] PD modeling of dataset with opposite values in the measurement effect Date: Fri, 27 Jan 2006 14:13:14 -0600 Li-Pin: I think that: a) your "base" model (Eo) is going to need to be dynamic, either as a function of drug concentration and/or duration of exposure. The change in Eo may possibly even be related to the magnitude of beta blockade achieved, and b) it doesn't sound like a very good beta-blocker Good luck. Paul