FW: question for absorption modeling

From: "Ritu Lal" Ritu.Lal@XenoPort.com Subject: [NMusers] FW: question for absorption modeling Date: Fri, 4 Nov 2005 08:41:54 -0800 Dear NM users, I am trying the following models for modeling the absorption phase of my compound. This is data for a drug administered orally. Currently, I am using ADVAN2 (one compt. oral absorption model with first order absorption and lag time), but there is some model misspecification in the absorption phase. These are the 2 other models I would like to try: 1. sequential first and zero-order abn with lag time, one compt model 2. only zero order absorption with lag time, one cpmpt model How do I set up my data file (how do I enter RATE for the zero-order absorption?) and control file for these 2 situations? Can I continue using the library models or do I need to switch to user written subroutines? Thanks, Ritu Ritu Lal, Ph.D. Sr. Director, Pharmacokinetics and Drug Metabolism Xenoport 3410 Central Expressway Santa Clara, CA 95051 Phone (408)616-7199 Cell (408)483-3741 Fax (408)616-7212 e-mail ritu.lal@xenoport.com