3 questions
From: musor000@optonline.net
Subject: [NMusers] 3 questions
Date: Mon, 17 Oct 2005 07:45:50 -0400
Hello PK Team,
Could somebody answer the following questions, please:
1. It is easy to specify initial conditions for differential equations
when they are simple functions of parameters in the model. Is that possible
to specify initial conditions in NONMEM when they are functions of both dose
and parameters in the model (Example: A(1)[T=0]=f(dose,Ke,Protein production,Vd))?
2. Can NONMEM change diffetential equations during integration process
between events? For example, if we have
A2=A(2)
A3=A(3)
IF (A2.LT.A3) THEN
DADT(2)=.....
DADT(3)=.....
ELSE
DATD(2)=...
DADT(3)=.....
ENDIF
Will NONMEM change differential equations during integration between events?
3. Is that possible/difficult to specify complex models of errors (constant CV,
exponential, etc.) in SAS? (I want to validate results using independent software.)
Thank you!
Pavel
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