RE: associatin/dissociation model
From: "Perez Ruixo, Juan Jose [PRDBE]" JPEREZRU@PRDBE.jnj.com
Subject: RE: [NMusers] associatin/dissociation model
Date: Thu, 6 Oct 2005 23:14:55 +0200
Hi Pavel,
I'm not sure what you mean with the model is non-linear. Do you mean the
disposition or the bioavailability? The first is included in the model, but
the second is not.
If you have IV and SC data you could do an exploratory deconvolution
analysis and explore if the dose normalized cumulative input change with the
dose. If that's the case probably the absolute bioavailability would
contribute to the nonlinearity as it happens for some biologicals.
Regards,
Juanjo.
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