RE: Re[2]: Covariance: Matrix=S or Matrix=R

From: "Stephen Duffull" sduffull@pharmacy.uq.edu.au Subject: RE: Re[2]: [NMusers] Covariance: Matrix=S or Matrix=R Date: Thu, 15 Sep 2005 09:05:31 +1000 Hi I think we can be a little more definitive. NONMEM uses a local search strategy and therefore you can never tell if it has reached a global minimum based on assessment of the R or S matrix. The NONMEM repository has plenty of discussions on the relevance of estimated standard errors (which I won't bring up here). Steve ==================================================================== Stephen Duffull School of Pharmacy, University of Queensland, Brisbane 4072, Australia Tel +61 7 3365 8808, Fax +61 7 3365 1688, Email: sduffull@pharmacy.uq.edu.au www http://www.uq.edu.au/pharmacy/index.html?page=31309 Design: http://www.uq.edu.au/pharmacy/sduffull/POPT.htm MCMC: http://www.uq.edu.au/pharmacy/sduffull/MCMC_eg.htm University Provider Number: 00025B