Subject: Re: Failing table step upon redefining ETAs as additive (or high correlations in $COV output)

From: J. Elassaiss-Schaap jeroen.elassaiss@organon.com Subject: Subject: Re: [NMusers] Failing table step upon redefining ETAs as additive (or high correlations in $COV output) Date: Wed, 24 Aug 2005 16:04:46 +0200 FYI: Upon further evaluation it appears that the apparent need for additive errors was an artifact due to the use of FO. Switching to FOCE/interaction and to an other variation on the structural model (iv2cmpt + lagged zero order absorption), the final model behaved well in terms of termination and prediction intervals - and utilized BW as a covar on CL. BTW, there is some literature out there suggesting that sc absorption might change with age. Today I serendipitously encountered the following reference: "The effect of aging on percutaneous absorption in man", Roskos et al., J Pharmacokinet Biopharm. 1989 Dec;17(6):617-30. Best regards, Jeroen J. Elassaiss-Schaap Scientist PK/PD Organon NV PO Box 20, 5340 BH Oss, Netherlands Phone: + 31 412 66 9320 Fax: + 31 412 66 2506 e-mail: jeroen.elassaiss@organon.com _______________________________________________________