Revision to NONMEM Tip #20 July 18, 2005

From: William Bachman Date: July 18, 2005 technical Source: cognigencorp.com
From: "Bachman, William (MYD)" bachmanw@iconus.com Subject: [NMusers] Revision to NONMEM Tip #20 July 18, 2005 Date: Mon, July 18, 2005 4:20 pm Corrections to NONMEM Tip #20 Issued April 29, 2004 1. Definition of LVR Original LVR: max. no. of eta's and epsilon's (includes off-diagonal variances (e.g. 50 off-diagonal variances would allow a full 10 x 10 diagonal matrix to be estimated) (user-defined, default is 30) Changed to LVR: max. no. of eta's and epsilon's (user-defined, default is 30) 2. Definition of LPAR Original LPAR: max. no. of parameters that may be estimated, LPAR=LTH + LVR (default is 70) Changed to LPAR: Max. no. of parameters that may be estimated, LPAR=LTH + LVR + off-diagonal variances (e.g. 50 off-diagonal variances would allow a full 10 x 10 diagonal matrix to be estimated) (user-defined, default is 70) Full text of tip may be found at: ftp://ftp.globomaxnm.com/Public/nonmem/tips/tip20-4-29-04.txt nmconsult@globomaxnm.com GloboMax The Strategic Pharmaceutical Development Division of ICON plc 6031 University Blvd. Suite 300 Ellicott City, MD 21043 410-696-3098 voice 410-480-0776 fax _______________________________________________________