End of semester MCQ and short answer question

From: "Nick Holford" n.holford@auckland.ac.nz Subject: [NMusers] End of semester MCQ and short answer question Date: Thu, July 14, 2005 8:54 pm Q 1. LLQ is the lower limit of quantitification. Do regulatory Pharmacometric groups endorse? a. Ignoring LLQ values b. Imputing LLQ values as 0 c. Imputing LLQ values as 0.5*LLQ d. Using the actual measurement i.e. ask the chemical analyst to tell the truth e. None of the above Q 2. Beal S. Ways to fit a pharmacokinetic model with some data below the quantification limit. Journal of Pharmacokinetics and Pharmacodynamics 2001;28(5):481-504 Has there been any advance on this in the last 4 years? Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/