RE: What does nonmem do after iteration stops? --> Further info

From: "Eleveld, DJ" d.j.eleveld@anest.umcg.nl Subject: RE: [NMusers] What does nonmem do after iteration stops? --> Further info Date: Wed, June 8, 2005 10:34 am I tried a few more things to determine the source of the post-iteration delay: 1) $TABLE --> delay 2) $TABLE NOAPPEND --> nodelay 3) $TABLE NOAPPEND but with DV and Y as columns --> nodelay 4) No tables but $COVARAINCE --> delay It appears that the OS/compiler is not the cause since even big tables can be made without any extra delay. Neither does it seem to be related to prediction since DV and Y can be included in a table without extra delay. So to be more specific the delay seems to follow covaraince calculation or residual and weighted residual calculation. I dont understand why this is. This could possibly be a model-related issue since the model I am fitting is unusual in that the bioavalability parameter F1 changes over time depending on a random variable defined in $PK. Nonmem seems to have trouble handling this variable, giving me strange ETA estimations and POSTHOC values equal for all individuals regardles of the estimated ETA value. I'm in the process of documenting this and will report back to the users group with more detailed information. Thanks very much, Doug Eleveld _______________________________________________________