Re: between-patient variability in PK and PD

From: "Alice Nichols" NICHOLA2@wyeth.com Subject: Re: [NMusers] between-patient variability in PK and PD Date: Wed, May 4, 2005 12:09 pm Its possible that effect is more related to overall exposure as opposed to individual time-concentration values, also it needs to be considered whether there is a delay between concnetrations and effect. Have you done hysteresis plots. Alice I Nichols, PhD Sr Director, Clinical Pharmacology Wyeth Research 500 Arcola Rd Collegeville, PA 19426 tel: 484-865-8741/ fax: 484-865-9075 nichola2@wyeth.com _______________________________________________________