RE: RES and WRES

From: "Andrew Hooker" Andrew.Hooker@farmbio.uu.se Subject: RE: [NMusers] RES and WRES Date: Sat, May 28, 2005 5:33 am Hi Leonid, The weighted residuals are calculated by dividing the vector of each individual's residuals (res_i) by the square root of the matrix of covariances of that individual's data conditional on the population model: WRES_i = RES_i / SQRT(COV(data_i | F_pop)) This means that for each WRES calculated we include covariances between data points of an individual. If the correlations between some of these data points are negative then the resulting WRES could also be negative, while the RES could be positive. -Andy Andrew Hooker, Ph.D. Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 751 24 Uppsala, Sweden Tel: +46 18 471 4304 http://www.farmbio.uu.se/research.php?avd=5 _____________________________________________________