a question about control file
From: chang tien hung [mailto:tagsokim@ms95.url.com.tw]
Subject: [NMusers] a question about control file
Date: Wednesday, May 25, 2005 12:16 AM
dear all:
i have a program about carbamazepine
As follow is my control file
i find it difficult to find initial value which can run successful
all the result tell me " ETA=0 balabala...."
how can i make it better ?
thank you .
chang tien hung
;Model Desc: cbz control48
;Project Name: carbamazepine
;Project ID: MODEL 49
$PROB RUN# cbzcontrol69tets70
$INPUT C ID SEX AGE WT EVID TIME AMT SS II DV MDV VAL PHE PHB MD
$DATA datacbz1.csv IGNORE=C
$SUBR ADVAN2 TRANS2
$PK
TVCL1=THETA(1)*AMT**THETA(4)*WT**THETA(5)*AGE**THETA(6)
TVCL2=THETA(7)**VAL*THETA(8)**PHE*THETA(9)**PHB*THETA(10)**SEX
TVCL=TVCL1*TVCL2
TVV=THETA(2)
TVKA=THETA(3)
CL=TVCL*EXP(ETA(1)); Clearance (mL/kg/d)
V=TVV*EXP(ETA(2)); Central volume (mL/kg)
KA=TVKA; Absorption rate (/d)
S2=V; Scale factor
$ERROR
Y=F*EXP(ERR(1))