RE: erros messages related to data file and/or NONMEM I/O
From: "Xiao, Alan" alan_xiao@merck.com
Subject: [NMusers] RE: erros messages related to data file and/or NONMEM I/O
Date: Thu, April 28, 2005 10:51 am
Hello,
Thank all those friends who kindly responded to my last email. It looks like
the discussion posted in the following link is relevant - special thanks to
Leonid for forwarding this to me.
http://www.cognigencorp.com/nonmem/nm/99oct041996.html
Based on this discussion, I slightly modified my model - still use my original
proportional residual model but add a very small additive error model (0.000001)
for test, the problem is gone.
Now, my question for your discussion is that why this happened to a data file (with a
limited dose range) but not others (e.g. a data file with the full dose range) even
both data files start with a concentration record (predose, but different ID) followed
by a dosing record - I used calendar date and clock time. Or is there anything else I'm missing?
Alan
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