RE: Window of absorption

From: "Gordi, Toufigh" Toufigh.Gordi@cvt.com Subject: RE: [NMusers] Window of absorption Date: Tue, March 29, 2005 1:20 pm Dear Majid, Two solutions come in my mind. Before describing them, let me just warn you that I have no experience with such a system and my proposals (specially the second one) might not work. Here they come: - Construct an absorption system with at least 2 compartments, similar to a transduction PD model, where you have the drug administered into the first compartment. Initial condition for the second compartment is equal to 0. The compound leaves the first compartment via 2 routs: absorption to the central compartment and transfer to the second absorption compartment. You may want to test whether a single KA will work for both compartments or if you need different ones for each absorption compartment. - Write an IF...THEN statement, where you have a KA until a certain time and another KA after that. As I said, I would start with the first option, as it is more close to what happens in reality: you have a transfer of your compound through the GI track with different segments having different absorption capacities. Toufigh