Re: Am I interpreting THETA(1) incorrectly?

From: "Liping Zhang" ZHANG_LIPING@lilly.com Subject: [NMusers] Re: Am I interpreting THETA(1) incorrectly? Date: Thu, March 24, 2005 10:28 am Doug, there is nothing mystery here. Just like if you random sample 10 normally distributed numbers with mean equal to 0, the mean of these ten numbers are not likely to be 0. Theta would be equal to the geometric mean of the posthoc individual parameter if posthoc individual parameters are log normal distributed and truly represented the distribution (theoretically you need infinite sample size). As for why the geometric mean of posthoc individual parameters are closer to the real values of theta, this could be caused by mere chance. You could do experiment: simulation different set of data and then compare the two. Liping Zhang, PhD Global PK/PD Modeling and Trial Simulation ELi Lilly & Company Work: 317-277-8687 Fax: 317-433-6661 DC 0734 Email: zhang_liping@lilly.com _______________________________________________________ F