Re: $DES block and T

From: "Sam Liao" sliao@pharmaxresearch.com Subject: Re: [NMusers] $DES block and T Date: Wed, February 9, 2005 6:38 pm Hi Lars: You do need to have the MDV record with time equal to zero in order to solve the differential equation correctly. You've done the right thing paying attention to the warning msg from nmv. It is trying to tell you that the ODE solver start from a time point which is not zero. That is why the results are different. Also on a different issue about your PKPD model, instead of using a threshold concentration in your model, have you try a Emax model (Hill's equation) with large gamma coefficient which can also give you a steep function to mimic the threshold model you have. Best regards, Sam Liao _______________________________________________________