How does NONMEM $DES work?
From: "Wang, Yaning" WangYA@cder.fda.gov
Subject: [NMusers] How does NONMEM $DES work?
Date: Tue, December 21, 2004
Nick:
I just want to make sure I correctly understand your response. By default,
NONMEM uses the value of C2(=1 in your example) at TIME2 as the value for C
throughout the interval from TIME1 (=1) to TIME2 (=2) in order to solve the
DE system for DV at TIME2 (=2). Is this right?
By following this, I derived the interpolated value for C between TIME1 and
TIME2.
Suppose at TIME=1.3, we assume C should be 0.3 based on a linear
interpolation.
In eqation CNOW=C-SLOPE*T, I think C=1 and SLOPE=1 at TIME=1.3(C2 and SLOPE2
in data set are used throughout the interval by default). In order to get
CNOW=0.3, T has to be 0.7 at TIME=1.3. How is T in $DES related to the TIME
variable in the data set?
Again, thanks a lot for the help.
Yaning