RE: SAS program or SAS macro to prepare NonMem ready data

From: "Chapel, Sunny" Sunny.Chapel@pfizer.com Subject: RE: [NMusers] SAS program or SAS macro to prepare NonMem ready data Date: Wed, December 8, 2004 2:03 pm I use SAS and Splus for Nonmem datasets, but I just want to point out that WinNonlin has some functionality for Nonmem data creation. (I don't know how good it is, though.) Splus is convenient but it doesn't handle large datasets very well because of its notorious "memory leak" problem. In other words, Splus keeps copies of intermediate datasets during calculation in the memory until it is sure that they are unnecessary. No loops with large objects! When Splus shows the "insufficient dynamic memory" message, the only way to be able to use Splus is to quit Splus and restart it. I'm a big fan of Splus, but I tend to use SAS more and more for data manipulation as the datasets I deal with become larger and larger. If I were new and needed to learn how to create Nonmem datasets, I would stick with SAS. I also think that the dream of automating Nonmem data creation won't come true soon. Sunny Chapel, PhD Clinical PK/PD Pfizer Ann Arbor Laboratory Sunny.Chapel@Pfizer.com