RE: Modeling with insufficient data

From:"Bhattaram, Atul" BhattaramA@cder.fda.gov Subject: RE: [NMusers] Modeling with insufficient data Date: Tue, October 26, 2004 6:48 am Hello Lim I dont think you need to model the drug and three metabolites. You could do with the drug and two metabolites (It depends on the time course of your metabolites relative to the parent drug). You can fix the volume of distribution of the metabolites to either 1 or some factor of the volume of distribution of the parent drug. You would have to worry about identifiability issues if you have insufficient data. Venkatesh Atul Bhattaram Pharmacometrics DPE-1, OCPB CDER, FDA.