saturable first-pass metabolism

From: "andy lie" zhenqung@yahoo.com Subject: [NMusers] saturable first-pass metabolism Date: Mon, October 4, 2004 10:32 pm All, I have a set of oral data that showed increase bioavailability with increasing dose and it follows a biphasic disposition with similar terminal half lives across different doses. However, I don't have IV data. Is that still a way to look at the change of F as a function of Dose in the 2-cmp model and can someone tell me the codes if possible??? Thanks. ZhenQung