Urinary excretion
From: Johan.Rosenborg@astrazeneca.com
Subject: [NMusers] Urinary excretion
Date: Tue, September 28, 2004 3:18 am
All,
I would like to fit a model simultaneously to plasma and urine data on a
substance that is almost exclusively eliminated via the kidneys - the
preliminary estimate using the F0 parameter is 98%.
My problem: urine recovery in some subjects is larger than the actually
administered dose
My question: How should I take into account the mass balance discrepancy?
/ Johan