NONMEM dataset development

From: "Renee Ying Hong" yinghong@pharm.usyd.edu.au Subject: [NMusers] NONMEM dataset development Date: Sat, September 4, 2004 11:56 pm Dear all, A few questions about developing the data set for NONMEM. 1. In NONMEM user manual V, it says that less than 50 data records are allowed for each individual. Does it mean that maximum 50 data records, which include dose records and observation records, are allowed for each individual? How to change this limit? 2. Is it correct that AMT and DV observed at the time when dose is given cannot be recorded in the same data record? 3. Some covariables are not available for some patients. Is it correct that dot or 0 should be used to indicate the missing values? 3. Some patients have the study drug for more than one occasion. NONMEM is employed to work out the BOV. Therefore, data item OCC is added in the data set to indicate the sequence of the occasion. Apart from that, what else should be included in the data set? Does the ID# for each occasion of the same patient keep the same? Many thanks! Ying Ying Hong Faculty of Pharmacy University of Sydney Tel: 61 2 9036 5025 Fax: 61 2 9351 4391 E-mail: yinghong@pharm.usyd.edu.au