Drug initially inhibits one enzyme and then the second enzyme isinduced

From: "Partha Nandy" partha.nandy@bms.com Subject: [NMusers] Drug initially inhibits one enzyme and then the second enzyme isinduced Date: Wed, September 1, 2004 7:27 am Hi All, I am trying to model some data for a drug that possibly acts on 2 enzymes. During the first few days it inhibits one enzyme, which is reflected in reduced clearance of the drug, but over the next few days a second set of enzyme(s) gets induced resulting in steady increase of clearance of the drug and from that point onwards it takes over. Here are some of the caveats.. - I do not have the metabolite data nor the enzyme characteristics. All I have are some preliminary findings. Therefore the model that I am contemplating is primarily an empirical one - The data during the first few days are sparse, mostly troughs, but I have intense data for rest of the days. I would appreciate your suggestions and help. Kind Regards, Partha Partha Nandy Clinical Discovery-BMS - _______________________________________________________