Simultaneous model of plasma and whole blood data

From: Fabrice Nollevaux fabrice_nollevaux@sgs.com Subject: [NMusers] Simultaneous model of plasma and whole blood data Date: Fri, August 6, 2004 11:10 am Dear All, In our study, a drug has been determined in both plasma and whole blood. How to simultaneously fit plasma and whole blood concentrations, given the particularity that one compartment (plasma) is included in the other (whole blood). Any NM-code example will be welcome. Moreover, drug levels are markedly lower in plasma than in whole blood, indicating a significant uptake of the drug by blood cells. Separately, plasma and whole blood concentrations are both well fitted using a three-compartmental mode, while we were expecting to need one additional compartment for plasma related to blood cells. Many thanks in advance for any suggestion in the interpretation of this situation. Fabrice Nollevaux, SGS Biopharma - Wavre - Belgium www.sgsbiopharma.com