RE: Indirect response model in NONMEM
From:"mathangi" mathangi@msn.com
Subject: RE: [NMusers] Indirect response model in NONMEM
Date: Wed, August 25, 2004 6:58 pm
Hello Toufigh,
In order to initialize the response compartment to the baseline value, you
can use the following addition in the code:
$PK
CL=CL1
...
IEFF=THETA(1)
IC50=THETA(2)*EXP(ETA(1))
KOUT=THETA(3)
KIN=THETA(4)
S2=VC
D2=DUR
F1=BAV
F5=KIN/KOUT ;Baseline value
And accordingly, the data file is arranged by including AMT=1 for CMT=5 at
TIME=0.
ID TIME AMT EFF CMT
1 0 100 0 1
1 0 1 0 5
1 0 0 14.739 5
1 0.25 0 12.633 5
1 0.5 0 10.043 5
1 0.75 0 9.5252 5
1 1 0 8.9563 5
1 1.5 0 6.5243 5
1 2 0 5.2844 5
1 2.5 0 4.6631 5
1 3 0 4.2629 5
1 4 0 3.5792 5
1 6 0 3.1123 5
1 8 0 3.275 5
Hope this helps
Mathangi Gopalakrishnan
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