RE: "First-pass" 3-compartment model

From: Luann Phillips luann.phillips@cognigencorp.com Subject: RE:[NMusers] "First-pass" 3-compartment model Date: Wed, August 11, 2004 6:47 pm Martin, There is not a standard ADVAN for this type model. If the system is linear, you could implement it with ADVAN5. If you have any nonlinearity then you would need to use ADVAN6. Example: Oral Drug(dose to depot) with first order absorption to the central compartment and elimination from the peripheral cmt. $PROB 3 cmt model with elim from peri $INPUT <> $DATA <> $SUBROUTINES ADVAN5 $MODEL COMP=(DEPOT,INITIALOFF,DEFDOSE) ;cmt=1 COMP=(CENTRAL) ;cmt=2 COMP=(PERI) ;cmt=3 $PK KA=THETA(1)*EXP(ETA(1)) CL=THETA(2)*EXP(ETA(2)) Q=THETA(3)*EXP(ETA(3)) VC=THETA(4)*EXP(ETA(4)) VP=THETA(5)*EXP(ETA(5)) S2=v2/1000; ;ADVAN5 expects Kij parameters where i=cmt number where flow originates ; j=cmt number where flow stops and 0=outside the system ; Note the following equations are just to demonstrate that you can ; still model macro parameters in ADVAN5 as long as you provide the ; equations for the micro rate constants. ; For ease of demonstration, the equations below are similar to those ; for a standard 2 cmt model with elimination from the central. ; I have not checked whether they are appropriate for a 2 cmt model with ; elimination from the peripheral. K12=KA ;flow from depot to central K23=Q/VC ;flow from central to peri K32=Q/VP ;flow from peri to central K30=CL/VP ;elimination from peri $ERROR same as usual Regards, Luann _______________________________________________________