Modeling of iv and po data

From: "Gordi, Toufigh" Toufigh.Gordi@cvt.com Subject: [NMusers] Modeling of iv and po data Date: Wed, August 11, 2004 4:31 pm Dear all, I am trying to model data from a study including both iv and po data. The bioavailability is quite low (~15%). The highest po doses given were 10 times higher than the highest iv dose. When modeling the iv data alone, a non-linear CL gives the best fit. Such a model, however, does not converge when iv and po data are combined. The major problem, I believe, is the estimation of ka. Any suggestion on how to proceed? And in general, if one of the characteristics of the model including iv data (let's say the non-linear CL) is masked by the PK profile after po, what would be the best approach to model the data? Model the data separately or apply a simpler model to the combined data set? best wishes, Toufigh Gordi