RE: Combined tissue and plasma concentration models

From: Nick Holford n.holford@auckland.ac.nz Subject: RE:[NMusers] Combined tissue and plasma concentration models Date: Mon, March 29, 2004 11:04 pm Garry, There is no reason in principle why you should not be able to specify a model for 4 matrices. The most straightforward method would be to code a set of differential equations defining a mammillary model (e.g. using ADVAN6). If the model is all first order then you can specify the model in a somewhat more abstract way using ADVAN7 or ADVAN5. In practice you may find it harder to fit all the data as well to a single connected model as you did with separate models. Fitting the data simultaneously is a good stress test for the validity of the assumptions made about how the observed concentrations are related to each other. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/