RE: time-controlled drug delivery

From: musor000@optonline.net Subject: RE: [NMusers] time-controlled drug delivery Date: Sun, March 21, 2004 11:06 pm Hi, Nick, Thanks for your help. I learn NONMEM by my own and try to replicate results from book by Gabrielson & Weiner. They use fixed phase and period. Problem is that I cannot get results which are similar to what I see in the book: AMPL=0.248013, V=2.119573, CL=0.048638. My amplitude is much smaller and standard errors of the estimates are much larger. Parameters I am geting are here: AMPL=0.0615, V1=1.59, K1=0.0326, CL=0.0518. They look stable. When I create a record with time=0 and mising dependent variable, the results are quite different: AMPL=0.0320, V1=2.12, K1=0.0239, CL=0.0507. They also look stable. Another problen is that NONMEM does not print the last record (time=300.5051). I can see this record when I add a missing record at the end of the data file and the results are different again.... (AMPL=0.0959, V1=2.44, K1=0.0191, CL=0.0466). I'll look at plots tommorrow. May be they will explain something. Here are modified data (with the first and the last missing records): 0 0 . 0 10.6061 0.5173 0 31.8182 0.8214 0 60.1010 1.8692 0 77.7778 1.4870 0 91.9192 1.4728 0 120.2020 2.4959 0 152.0202 1.5575 0 201.5152 1.5988 0 229.7980 2.3068 0 300.5051 2.5459 0 360.0 . Thank you, Pavel _______________________________________________________