Re: Implementation of interindividual variability in residual variance
From: Thomas_Kerbusch@sandwich.pfizer.com
Subject: Re: [NMusers] Implementation of interindividual variability in residual variance
Date: 2/18/2004 9:57 AM
Atul,
We have recently gained some experience in accounting for the individual
contribution to the residual error. When we pooled data from different
studies in patients, healthy volunteers and involving different
formulations, it was anticipated that the residual error would not be
constant across all individuals. We have published the application of this
methodology in BJCP:
Kerbusch T, Whlby U, Milligan PA, Karlsson MO. Br J Clin Pharmacol, 2003;
56(6): 639-652
Kerbusch T, Milligan PA, Karlsson MO. Br J Clin Pharmacol, 2004; 57(2):
170-180
With friendly regards,
Thomas Kerbusch
Clinical PK/PD, Modelling & Simulation
Pfizer Global R&D, Sandwich, UK