RE: reporting "errors" or "bugs" to nmusers -> -O3 optimization r esults corroborated
From: "Bachman, William (MYD)" bachmanw@iconus.com
Subject: RE: reporting "errors" or "bugs" to nmusers -> -O3 optimization r esults corroborated
Date: 12/16/2003 9:56 AM
Erik,
My results with gcc 3.2.2 on Red Hat Linux 9 are as follows:
-O and '-O3 -fno-gcse':
MINIMIZATION TERMINATED
DUE TO PROXIMITY OF LAST ITERATION EST. TO A VALUE
AT WHICH THE OBJ. FUNC. IS INFINITE (ERROR=136)
obj. fcn for -O: 785.8
obj. fcn for '-O3 -fno-gcse': 498.5
-O3: PK PARAMETER FOR K12 IS NON-POSITIVE
These results corroborate your results. Additionally, results with runs of
CONTROL5 and THEOPP (distributed with NONMEM) indicate there indeed is a
problem with -O3 optimization in general:
-O and '-O3 -fno-gcse': minimization successful
-O3: PK PARAMETERS FOR KA AND K ARE EQUAL
Thank you for providing the additional information to evaluate the issue.
My recommendation for g77 would be to use -O optimization for versions 3.2.2
and 3.2.3 and test optimization options for future versions.
Have you been able to get any additional information on the source of the
problem?
Bill
nmconsult@globomaxnm.com
GloboMax
The Strategic Pharmaceutical Development Division of ICON plc
7250 Parkway Drive, Suite 430
Hanover, MD 21076
Voice: (410) 782-2205
FAX: (410) 712-0737
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