Subject: Error message: NO MORE THAN 20 ADDITIONAL AND/OR LAGGED DOSE RECORDS ~

From: BellyGom@aol.com Subject: Subject: [NMusers] Error message: NO MORE THAN 20 ADDITIONAL AND/OR LAGGED DOSE RECORDS ~ Date: 11/5/2003 12:12 PM Dear Dr. Bachman, Thanks for your interest in the problem; do you have some idea what might be wrong with the model? It actually runs okay(??) after eliminating subjects causing the message at the bottom; the original data size is approx. 6000*20 and after eliminating those subjects, it is approx. 4000*20. I indeed have many dose/lagged dose records per subject since I have duplicated the multiple dosing events for comp. 1 (central) 4 times, for 4 additional lagged compartments; the amounts in the four comp.s characterises the drug effect. And samples are often Very sparse. I will be more than happy to provide further information to resolve this matter.... (I just don't know which is relevant...) Many many thanks, In-Sun MONITORING OF SEARCH: 0PRED EXIT CODE = 1 0INDIVIDUAL NO. 10 ID=0.16000000E+02 (WITHIN-INDIVIDUAL) DATA REC NO. 130 THETA= 1.44E+02 2.40E+02 1.00E+01 1.11E+01 3.16E+02 2.04E+00 2.05E+02 5.48E-01 1.00E+00 1.20E+00 2.91E-01 4.36E+01 NO MORE THAN 20 ADDITIONAL AND/OR LAGGED DOSE RECORDS MAY BE ACTIVE AT ONE TIME 0PROGRAM TERMINATED BY OBJ MESSAGE ISSUED FROM ESTIMATION STEP AT INITIAL OBJ. FUNCTION EVALUATION 1THERE ARE ERROR MESSAGES IN FILE PRDERR