interpretation of WRES of logarithmically transformed data
From: Anthe Zandvliet Apaza@SLZ.NL
Subject: [NMusers] interpretation of WRES of logarithmically transformed data
Date: 11/21/2003 5:40 AM
Dear all,
I have fitted the natural logarithms of measured concentrations
to a PK model. The error block is given below.
$ERROR
IF (DV.EQ.0) THEN
IPRED=-3
ELSE
IPRED=LOG(F)
ENDIF
Y=IPRED+THETA(10)*EPS(1)
W=IPRED
IRES=DV-IPRED
IWRES=IRES/W
EPS(1) is fixed at 1.
In order to interpret the output of my runs, I should calculate EXP(DV),
EXP(PRED) and EXP(IPRED) of the logarithmic DV's, PRED's and IPRED's
to obtain the linear values.
However, I can not transform WRES values to their corresponding linear
values. Does anyone have suggestions how to interpret the WRES values
that are calculated by NONMEM?
Thank you!
Best regards,
Anthe Zandvliet
Slotervaart Hospital
Dept. Pharmacy and Pharmacology
Louwesweg 6
1066 EC AMSTERDAM
The Netherlands
Telephone +31 20 512 4657
FAX + 31 20 512 4753