t-distribution =scaled mixture of normal distributions
From: "WANG,YANING" <yaning@ufl.edu>
Subject: [NMusers] t-distribution =scaled mixture of normal distributions
Date: Thu, 24 Jul 2003 10:52:28 -0400 (EDT)
Dear Dr. Piotrovsky:
Thanks for your response. It seems that NONMEM has to turn to the original
way of dealing with t-distribution--scaled mixture of normal distributions
(to be exact, scaled by a gamma distribution). Maybe it is easier to explain
the results in terms of a heterogeneous population with different normal
distributions rather than a general t-distribution with a degree of freedom.
Is this the reason why NONMEM doesn't have t-distribution which is quite
common in most of other softwares?
Thanks
Yaning Wang
Department of Pharmaceutics
College of Pharmacy
University of Florida