RE: DV simulation problem

From:VPIOTROV@PRDBE.jnj.com Subject:RE: [NMusers] DV simulation problem Date:Fri, 6 Jun 2003 11:22:43 +0200 Dan, When you simulate the model without fitting it back to simulated data sets ($SIM ONLY) PRED item in the table corresponds to population predictions (determined by THETA and not affected by ETA and EPS). IPRE, if you define it as IPRE=F, gives individual predictions (determined by THETA and ETA (OMEGA), but not affected by EPS, i.e. noise free). DV is determined by THETA, ETA (OMEGA) and EPS (SIGMA), and because of this is noisy. The bigger is SIGMA the more pronounced is the noise. Best regards, Vladimir ----------------------------------------------------------------- Vladimir Piotrovsky, Ph.D. Research Fellow, Advanced PK-PD Modeling & Simulation Global Clinical Pharmacokinetics and Clinical Pharmacology (ext. 5463/151) Johnson & Johnson Pharmaceutical Research & Development Turnhoutseweg 30 B-2340 Beerse Belgium Tel: (+3214) 605463 Fax: (+3214) 605834 Email: vpiotrov@prdbe.jnj.com