RE: Poor PRED estimates
From: "Gobburu, Jogarao V"
Subject: RE: [NMusers] Poor PRED estimates
Date: Thu, 22 May 2003 13:04:23 -0400
Hello,
It is going to be difficult to guess what the problem might be. But I will
anyways. It appears from the stumped pop predictions that the absorption
model might need improvement. You might want to test if the models in the
following article could be of help to you. Rich absorption phase data could
be challenging sometimes.
Holford NH, Ambros RJ, Stoeckel K. Models for describing absorption rate and
estimating extent of bioavailability: application to cefetamet pivoxil.J
Pharmacokinet Biopharm 1992 Oct;20(5):421-42
Regards,
Joga Gobburu,
Pharmacometrics,
CDER/FDA.