RE: Log-transformation

From: "Kowalski, Ken" Subject:RE: [NMusers] Log-transformation Date: Wed, 9 Apr 2003 08:35:57 -0400 Vladimir, I agree which is why I commented that when using such a model a reasonable estimate of M should be around the QL or lower. I suspect in your case if you can observe a 2nd elimination phase (beta) above the QL but you only fit a one-compartment model then M will be estimated to a value perhaps considerably higher than the QL. In this case I would be very much concerned with using this error model. However, if you have rich enough information to fit a 2-compartment model (i.e., dense sampling) it seems to me that although M may pick up some of the lack-of-fit when fitting a 1-compartment model, we would probably still see some lack-of-fit in our diagnostic plots that would suggest fitting a 2-compartment model. Regards, Ken _______________________________________________________