Re: Fixed or estimated?

From:Liping Zhang Subject:Re: [NMusers] Fixed or estimated? Date:Friday, March 28, 2003 2:34 PM -0700 Dear Toufigh, I agree with Dr. Gibiansky's recommendation completely. If you are interested in PD model, an additional reason for using the all-para-free model is that when you simulate (the ultimate goal of modeling), that is the model you will use. If you use the fixed-PK model analysis results to simulate, then you are not really simulating from the same model as your data-analytic model. About the OFV, I agree with Dr. Bachman, too. For the fixed-PK analysis, you did not indicate whether you included BOTH PK and PD data to estimate PD when you fixed the PK para to estimate PD. If you do not include both, there is no comparison between two OFVs. Best regards, Liping Zhang _______________________________________________________