separate parameter estimates
From: Johnmo777
Subject: [NMusers] separate parameter estimates
Date:Wed, 12 Mar 2003 10:21:42 -0800 (PST)
Dear All,
If you would like to obtain separate estimates for a
specific parameter such as Ka based upon, for example,
two different dose formulation groups, is it necessary
to initially set typical values to zero? For example:
TVKA1=0
TVKA2=0
IF (DOSE.EQ.1) THEN
TVKA1=THETA(1)
KA=TVKA1*EXP(ETA(1))
ENDIF
IF (DOSE.EQ.2) THEN
TVKA2=THETA(2)
KA=TVKA2*EXP(ETA(2))
ENDIF
I ask because when looking at post hoc estimates, I've
noticed that regardless of dose group (1 or 2) every
patient ends up with both typical value estimates of
TVKA1 and TVKA2. Is this not a problem? Is there
another way of coding to be sure the correct typical
value is applied to the correct patient?
Thanx,
jm