separate parameter estimates

From: Johnmo777 Date: March 12, 2003 technical Source: cognigencorp.com
From: Johnmo777 Subject: [NMusers] separate parameter estimates Date:Wed, 12 Mar 2003 10:21:42 -0800 (PST) Dear All, If you would like to obtain separate estimates for a specific parameter such as Ka based upon, for example, two different dose formulation groups, is it necessary to initially set typical values to zero? For example: TVKA1=0 TVKA2=0 IF (DOSE.EQ.1) THEN TVKA1=THETA(1) KA=TVKA1*EXP(ETA(1)) ENDIF IF (DOSE.EQ.2) THEN TVKA2=THETA(2) KA=TVKA2*EXP(ETA(2)) ENDIF I ask because when looking at post hoc estimates, I've noticed that regardless of dose group (1 or 2) every patient ends up with both typical value estimates of TVKA1 and TVKA2. Is this not a problem? Is there another way of coding to be sure the correct typical value is applied to the correct patient? Thanx, jm
Mar 12, 2003 Johnmo777 separate parameter estimates
Mar 12, 2003 Nick Holford Re: separate parameter estimates