RE: Covariate effect

From: Jogarao V Gobburu Date: March 07, 2003 technical Source: cognigencorp.com
From: "Gobburu, Jogarao V" Subject:RE: [NMusers] Covariate effect Date:Fri, 7 Mar 2003 18:17:50 -0500 The case you describe is not unusual. I am assuming there is not much prior information about this covariate. If there is no drop in the unexplained variability, inspite of having a significant drop in OFV, the full model might not be of practical use (for example dose adjustment). But certainly it might be a signal to probe more into influential individuals/data points (Mats Karlsson performed some work on these lines). Another source of this happening could be that it is false-positive finding. Regards, Joga Gobburu Pharmacometrics CDER, FDA

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Mar 07, 2003 Toufigh Gordi Covariate effect
Mar 07, 2003 Serge Guzy RE: Covariate effect
Mar 07, 2003 Jogarao V Gobburu RE: Covariate effect
Mar 10, 2003 Kenneth Kowalski RE: Covariate effect
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