Bioavailability and P-Gp
From:Prof LJ Van Obbergh
Subject:[NMusers] Bioavailability and P-Gp
Date:Tue, 28 Jan 2003
Dear friends,
we would like to determine the bioavalability of a drug transported through
the intestinal barrier by P-Gp before and after blocking of P-Gp in children.
by comparaison of the AUC obtained with an iv and and oral dose.
Would it be possible to conduct this study with a population approach as we
would like to limit the amount of blood samples.
If yes, how would you write the control stream for NONMEM describing this
approach????
thank you in advance for your help.
Prof LJ Van Obbergh
Anaesthesia
University Clinics St Luc
Catholic University of Louvain
10 1821 av Hippocrate
1200 Brussels
Tf 3227641821
Fax 3227643699