weight as a covariate in kids

From:"Bonate, Peter" Subject:[NMusers] weight as a covariate in kids Date:Wed, 30 Oct 2002 08:52:50 -0600 Dear all, I am sure this will generate a lot of traffic but I have a question. In developing a model in kids (infants,neonates, and children) should weight be included as an a priori covariate used in the development of the structural model even if its inclusion does not improve the goodness of fit. I have heard alot of people say 'yes' but I wanted to get a group opinion. Then if so, should it go on all structural parameters, except perhaps absorption-related terms? And should it always be modeled as a power function? Let the games begin. Thanks, pete Peter L. Bonate, PhD Director, Pharmacokinetics ILEX Oncology, Inc 4545 Horizon Hill Blvd San Antonio, TX 78229 phone: 210-949-8662 fax: 210-949-8487 email: pbonate@ilexonc.com