ADVAN3 vs ADVAN6
From: "Venkatesh Atul Bhattaram"
Subject:[NMusers] ADVAN3 vs ADVAN6
Date:Tue, 8 Oct 2002 15:12:38 -0400
Hello All
I am analysing a single dose infusion data set which is a mixture of rich and sparse data using
FOCE and Wings for NONMEM. Initially I used ADVAN6 TRAN1(TOL 3) and later on tried to move to a faster
method ADVAN3 TRANS4. But the results are different here.
ADVAN6 TRANS1:
THETA: POPCL POPV POPQ POPV2
ETA: ETACL ETAV ETAQ ETAV2 BOV5 BOV6 BOV7 BOV8 BOV9 BOV10 BOV11
ERR:
XXX.lst 17695.720 eval=661 sig=+3.5 sub=139 obs=1028 CCIL=YNNN NV1.1 PIV1.1
THETA = 2.96 5.94 1.48 3.79
ETASD = 0.503984 0.343511 0c 0.184932 0.0639531 0.0639531 0.0639531 0.0639531 0.0639531 0.0639531 0.0639531
ERRSD = 0.199499 1.35277
THETA:se% = 6.7 4.9 12.6 6.4
OMEGA:se% = 38.5 35.6 0.0c 76.9 61.1 0.0 0.0 0.0 0.0 0.0 0.0
SIGMA:se% = 19.1 35.4
MINIMIZATION SUCCESSFUL
But when I was trying to shift to ADVAN3 TRANS4 I am getting this output:
THETA: POPCL POPV POPQ POPV2
ETA: ETACL ETAV1 ETAQ ETAV2 BOV5 BOV6 BOV7 BOV8 BOV9 BOV10 BOV11
ERR:
xxxx.lst 17737.737 eval=810 sig=1.9 sub=139 obs=1028 CCIL=YNNN NV1.1 PIV1.1
THETA = 3.01 5.96 2.12 3.7
ETASD = 0.470106 0.337639 0c 0.374166 0.0730753 0.0730753 0.0730753 0.0730753 0.0730753 0.0730753 0.0730753
ERRSD = 0.20567 1.98746
MINIMIZATION TERMINATED
DUE TO ROUNDING ERRORS (ERROR=134).
This is a little bit confusing. What could be the reason? Is it OK for me to rely on my ADVAN6 results?
I can send out my datasets if anybody else wants to evaluate.
Thanks in advance for your time.
Venkatesh Atul Bhattaram
Post-doctoral Fellow
University of Florida
Gainesville-32610
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