Error Message from NONMEM :: MINIMIZATION TERMINATED (ERROR=136)
From:"Nandy, Partha"
Subject:[NMusers] Error Message from NONMEM :: MINIMIZATION TERMINATED (ERROR=136)
Date:Wed, 18 Sep 2002 15:19:15 -0400
Hi,
I am sure NONMEM users have encountered this problem before. In the past, I
have been able to by-pass this problem by providing different initial
estimates for THETAs, OMEGAs and SIGMAs.
Now, I am encountering this problem again and my previous methods of solving
the problem is not working. Currently, I am running a$PRED routine. This
routine runs fine when Method=0 is implemented, but I am getting this
recurrent message, shown below, when I am trying Method=1 with interaction.
I have tried different initial estimates and also giving better initial
estimates (results from method=0 run, offset by ~10-20% etc..), deleting
records with DV=0, but I keep getting this message back.
I appreciate any help you can provide.
Thanks in advance.
Partha
Partha Nandy, Ph.D.
Clinical Pharmacology
partha.nandy@pharma.com
----------------------------------------------------------------------------
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0MINIMIZATION TERMINATED
DUE TO PROXIMITY OF LAST ITERATION EST. TO A VALUE
AT WHICH THE OBJ. FUNC. IS INFINITE (ERROR=136)
0AT THE LAST COMPUTED INFINITE VALUE OF THE OBJ. FUNCT.:
ERROR IN NCONTR WITH INDIVIDUAL 74 ID=0.74000000E+02
NUMERICAL HESSIAN OF OBJ. FUNC. FOR COMPUTING CONDITIONAL ESTIMATE
IS NON POSITIVE DEFINITE
THETA=
4.49E+01 1.03E+02 1.19E+01 8.23E+00 1.43E+00 4.25E-01 2.26E-01
2.88E+00 4.21E+00 7.05E-01
2.30E+00 4.32E-01 2.56E+00 1.64E+00 1.24E+00 8.85E-01
NO. OF FUNCTION EVALUATIONS USED: 1084
NO. OF SIG. DIGITS UNREPORTABLE
ETABAR IS THE ARITHMETIC MEAN OF THE ETA-ESTIMATES,
AND THE P-VALUE IS GIVEN FOR THE NULL HYPOTHESIS THAT THE TRUE MEAN IS 0.
ETABAR: -0.49E+00 0.28E+00 -0.12E-01 -0.13E+00 -0.19E+00 0.21E+00
P VAL.: 0.19-205 0.72E-71 0.38E-01 0.17E-01 0.51E-03 0.16E-05
Partha
Ext # 8320
Fax: 203-588-6328